Research Summary of Thomas G. Coleman, Ph.D.

Research Summary of Thomas G. Coleman, Ph.D.

My research involves building and solving mathematical models of physiological systems. Model building consists of creating accurate yet not overly complex mathematical descriptions of physiological phenomena. Model solving focuses on obtaining fast and accurate solutions to the model's equations -- which are typically non-linear algebraic and differential equations.

The emphasis is on organ level interactions. Of particular interest are non-linear and time-dependent behavior.

The goal is to improve our understanding of physiological systems, particularly complex ones. Insight is gained by studying a model's responses to a wide variety of parametric disturbances and comparing these responses to available clinical and experimental data. This insight is then used to improve the model's structure and quantitation in an iterative fashion.