Contact Information:

Department of Physiology
2500 North State Street
Jackson, MS 39047
Phone:  (601) 984-1806
Fax:   (601) 984-1817
Email:tadair@physiology.umsmed.edu

Related Research Areas:

Angiogenesis, Microcirculation, Vascular Biology

Research Interests:

Research Interests: Our overall hypothesis is that vascular growth and regression is regulated by functional requirements of local tissues. Angiogenesis is regulated by metabolic factors in tissues where blood vessels have primarily a nutritive function (heart, brain, skeletal muscle). Hypoxia stimulates VEGF dependent angiogenesis in these tissues. Our studies indicate that expression of VEGF, VEGFR-1, VEGFR-2, angiopoietin -1 and -2, and Tie-2 is subject to negative feedback regulation during long-term exercise conditioning in mice. More recent studies have shown that renal angiogenesis is likely to be controlled to some extent by non-metabolic processes. Our current focus is directed toward understanding control of angiogenesis in the kidney.

Research Methods:

Quantitative assessment of angiogenesis in vivoAngiogenesis assays (chick CAM, angiogenesis ex vivo)Molecular and biochemical assays (Real-time RT-PCR, Western Blot, ELISA)Quantitative morphometric and stereologic analyses of vasculature