Terry M. Dwyer, M.D., Ph.D.
Department
of Physiology & Biophysics and
Division of Critical Care, Respiratory and
Sleep Medicine,
Department of Medicine
Room number N608, N610 and N321-2
PHONE: (601) 984-1804 and (601) 984-6941
FAX: (601) 984-1817
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Research Interests
Mechanisms
of fluid and protein secretion in the airways.
Properties of the extracellular
matrix of the renal medulla
Techniques
Cell
biology; chromatography including HPLC and FPLC; fluorescence assays; receptor
binding assays; patch clamp; ELISA assays.
Research
Summary
I. Airways require a thin coating of fluid to maintain
healthy; too much, or fluid that contains too much mucus restricts airflow, or
allows for the colonization by pathogenic bacteria. Many inflammatory processes
combine to both increase the quantity of fluid, and alter its physical character.
We are currently investigating the cellular mechanisms by which inflammation alters
airway fluid, as well as non-invasive methods of monitoring airway fluid composition.
II. Blood pressure increases (on average) with adiposity; in Western societies,
this means that blood pressure increases with the weight gain that accompanies
aging. Renal function is altered in human and animal models of obesity (increased
renal blood flow and glomerular filtration), as is renal structure (increased
fat in the renal sinus, and increased medullary interstitial volume due to elevated
levels of hyaluronic acid). We are studying the mechanisms by which the interstitium
is altered, and the functional consequence of those changes.
Selected
Articles
Dwyer TM. The electrochemical basis of
nerve function. Fundamental Neuroscience for Basic and Clinical Applications.
D. E. Haines (Ed.). Churchill Livingstone Elsevier. Philadelphia. 2006.
Dwyer
TM and Schmidt-Nielsen B. The Renal Pelvis: Machinery That Concentrates Urine
in the Papilla. News in Physiol. Sci. 18: 1-8, 2003.
Knepper
MA, Saidel GM, Hascall VC and Dwyer TM. Solute concentration in the renal inner
medulla: Interstitial hyaluronan as a mechano-osmotic transducer. Am. J. Physiol.
(Renal Physiol.) 284: F1-F15, 2003. short review/book chapter
Lohmeier TE, Dwyer TM, Hildebrandt DA, Irwin ED, Rossing MA, Serdar DJ, Kieval
RS. Influence of prolonged baroreceptor activation on arterial pressure in angiotensin
hypertension. Hypertension. 2005 Nov. 46(5):1194-2000
Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden
WJ, Corradi M, Dekhuijzen R, Dweik RA, Dwyer T, Effros R, Erzurum S, Gaston B,
Gessner C, Greening A, Ho LP, Hohlfeld J, Jobsis Q, Laskowski D, Loukides S, Marlin
D, Montuschi P, Olin AC, Redington AE, Reinhold P, van Rensen EL, Rubinstein I,
Silkoff P, Toren K, Vass G, Vogelberg C, Wirtz H; ATS/ERS Task Force on Exhaled
Breath Condensate Exhaled breath condensate: methodological recommendations and
unresolved questions. Eur Respir J. 2005 Sep;26(3):523-48.
